The channel started in 2001, and the "E" stands for entertainment, and the channel is mainly aimed at the 15–35 age group. E4's most popular TV programmes are The Inbetweeners and The Big Bang Theory.
The IT Crowd was a British sitcom by Channel 4, written by
Graham Linehan, produced by Ash Atalla and starring Chris O'Dowd, Richard
Ayoade, Katherine Parkinson, Noel Fielding and Matt Berry. The "IT"
in the show's title can be pronounced as the letters IT /ˌaɪˈtiː/, as in the
abbreviation for information technology, or as the word "it".
https://en.wikipedia.org/wiki/E4_%28TV_channel%29